T cells |
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| 2007-11-06 | No history |  | Add My version | |
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Medicine. | |
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T cells
alpha-beta
CD 8
cytotoxic
Th1 cytokine profile
kills infected cell
lysomes
perforin
granzymes
co stim = CD 28 + 86
respond to fas ligand
suicide
CD 4
helper
Th0
naive
differentiate w/ APC cytokines +
CD 86, MHC + peptide
IL12
Th1
bact. inf.
inflammation
B class switch
IgG
inhibit Th2
MO
ROS
+ MHC
divide
sensitivity
IL 10
Th2
B class switch
IgG
IgE
IgA
- MO
inhibit Th1
+ mast
+ eosino
allergy
IL 10 mucous
Th3
inhibit Th1 + Th2
oral tolerance
anergy
deletion
Th3
dose
high
deletion
low
Th3
recognize MHC + peptide
development
thymus as double positive
not specific
dend. filter (MHC I + II available)
bind to MHC
I
CD 8
II
CD 4
down reg. other CD
single positve
tolerance
central
look at thymus
self peptide
no binding
DUD
deathrow
strong bind to peptide
deletion
fit MHC, low peptide
live
exit
peripheral
keep T in check
not all peptides exist
in thymus
2 signal hypothesis
1
MHC + peptide
2
co-stimulation
CD 86 on APC
(danger sig.)
only expressed from TLR
stimuli during infection
CD 28 on T
only 1
anergy
misc.
no som. hypermut.
no receptor editing
one binding site
V-J rearrangement
gamma-delta
ancient
mucous
recognize whole antigen
no thymus/lymph travel
present without infection
innate like
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